Entresto
Sacubitril/ValsartanIndications
- Used to treat specific types of heart failure.
- May increase lifespan and reduce the likelihood of hospitalization due to heart failure.
- Contains two medications: sacubitril and valsartan.
- Sacubitril is a neprilysin inhibitor, and valsartan is an angiotensin receptor blocker (ARB).
- Mechanism: Relaxes blood vessels, facilitating smoother blood flow and easing the heart’s pumping function.
Dosage and administration
- Read the Patient Information Leaflet before starting the medication.
- Take the product orally, with or without food, as directed by the doctor, usually twice daily.
- Dosage is determined by medical condition and response, with children’s dosage based on weight.
- Shake the suspension form well before each dose, measuring carefully with a special device/spoon.
- Doctor may advise starting at a low dose and gradually increasing to reduce side effect risks.
- Avoid taking with ACE inhibitors to prevent serious side effects; allow at least 36 hours between doses.
- Take regularly at the same times each day for maximum benefit.
- Inform the doctor if there’s no improvement or if the condition worsens.
Side effects
- Possible side effects include cough, dizziness, and lightheadedness.
- Inform your doctor if these effects persist or worsen.
- To minimize dizziness, rise slowly from sitting or lying positions.
- Medication is prescribed based on the doctor’s assessment of benefits outweighing risks.
- Serious side effects may include signs of kidney problems or high potassium levels.
- Seek immediate medical attention for a rare but severe allergic reaction, indicated by rash, swelling, or difficulty breathing.
- The provided list doesn’t cover all possible side effects; contact your doctor for unlisted effects.
Precautions
- Inform your doctor or pharmacist about any allergies, particularly to sacubitril, valsartan, other ARBs, or ACE inhibitors.
- Discuss your medical history, especially liver or kidney disease, dehydration, high blood potassium levels, or a history of serious allergic reactions.
- This product may cause dizziness; avoid activities requiring alertness until certain. Limit alcohol and marijuana use.
- Consult your doctor before using potassium supplements or salt substitutes containing potassium.
- Inform medical professionals about all products you use before surgery.
- If pregnant or planning pregnancy, discuss the risks and benefits with your doctor. Valsartan may harm the unborn baby.
- Consult your doctor before breastfeeding, as it is unknown if the product passes into breast milk.
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