Indications
- Olanzapine is used to treat mental/mood disorders, including schizophrenia, bipolar disorder, and depression (in combination with other medications).
- It is classified as an atypical antipsychotic, working to restore the balance of certain natural substances in the brain.
- Consider discussing the risks and benefits of treatment, particularly in teenagers, with your doctor.
- See the Precautions section for additional information.
Dosage and administration
- Read the Medication Guide provided by your pharmacist before starting olanzapine and with each refill. Ask your doctor or pharmacist if you have questions.
- Take this medication orally, with or without food, as directed by your doctor, usually once daily.
- The dosage is determined by your medical condition and response to treatment. Your doctor may start you at a low dose and gradually increase it to reduce the risk of side effects.
- Take the medication regularly at the same time each day to maximize its benefits. Even if you feel well, do not stop taking it without consulting your doctor.
- Inform your doctor if your condition persists or worsens.
Side effects
- Common side effects may include drowsiness, dizziness, upset stomach, dry mouth, constipation, increased appetite, or weight gain. Inform your doctor if these persist or worsen.
- To reduce the risk of falling, get up slowly from a sitting or lying position if you experience dizziness or lightheadedness.
- Serious side effects may include difficulty swallowing, tremors, slow heartbeat, fainting, mental/mood changes, numbness/tingling, yellowing eyes/skin, severe abdominal pain, trouble urinating, or interrupted breathing during sleep. Seek immediate medical attention if you experience these.
- This medication may increase blood sugar levels, potentially causing or worsening diabetes. Monitor blood sugar regularly if you have diabetes and notify your doctor of any changes.
- Olanzapine may lead to significant weight gain and elevated cholesterol/triglyceride levels, especially in teenagers, increasing the risk of heart disease. Discuss these risks with your doctor.
- Tardive dyskinesia, an uncommon but potentially permanent condition causing uncontrolled movements, may occur. Report any unusual movements to your doctor.
- Increased prolactin levels may result in unwanted breast milk, menstrual changes, or fertility issues. Males may experience sexual difficulties or enlarged breasts. Notify your doctor if these symptoms arise.
- Seek immediate medical help if you experience seizures, a rare but serious side effect.
- Neuroleptic malignant syndrome (NMS), a severe condition, may rarely occur, characterized by symptoms like fever, muscle stiffness, confusion, and rapid heartbeat. Seek immediate medical attention if you observe these symptoms.
- Very serious allergic reactions are rare but require immediate medical attention. Symptoms include fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.
- This list does not cover all possible side effects, and you should contact your doctor or pharmacist for any unlisted effects.
Precautions
- Inform your doctor or pharmacist about any allergies to olanzapine or related substances. Inactive ingredients in the medication may cause allergic reactions.
- Provide your medical history, especially if you have liver problems, seizures, difficulty swallowing, low white blood cell count, dementia, urinary issues, glaucoma, intestinal problems, smoking habits, diabetes history, heart disease, high cholesterol/triglycerides, or sleep apnea.
- Olanzapine can induce dizziness or drowsiness, which may be intensified by alcohol or marijuana use. Avoid activities requiring alertness until you can do them safely.
- Notify your doctor or dentist of all products you use before undergoing surgery.
- The medication may reduce sweating, increasing the risk of heat stroke. Avoid overheating, especially in hot weather, and seek medical help if experiencing symptoms like fever, mental/mood changes, headache, or dizziness.
- Teenagers may be more prone to side effects, including weight gain, elevated cholesterol, triglycerides, and prolactin levels.
- Older adults may be more sensitive to side effects, leading to an increased risk of falling.
- During pregnancy, use olanzapine only, if necessary, as it may lead to symptoms in newborns. Do not stop the medication without consulting your doctor, especially if planning pregnancy.
- Olanzapine passes into breast milk, potentially affecting the nursing infant. Inform your doctor if your baby shows signs of stiffness, shakiness, sleepiness, or difficulty feeding.
- This information does not endorse stopping medication for mental/mood disorders without consulting your doctor. If you plan to become pregnant or suspect pregnancy, discuss the risks and benefits with your doctor.