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• Read the Medication Guide provided by your pharmacist before starting mirtazapine and with each refill. Direct any questions to your doctor or pharmacist.
• Take the medication by mouth with or without food, usually once daily at bedtime, as directed by your doctor. The dosage is determined by your medical condition and response to treatment.
• Use the medication regularly for optimal benefits. To aid in remembering, take it at the same time daily. Improvement in symptoms may take 1 to 4 weeks. Do not increase the dose or take it more frequently than prescribed.
• Continue taking the medication even if you feel well. Consult your doctor before stopping the medication, as some conditions may worsen with abrupt discontinuation. A gradual decrease in dose may be necessary.

• Possible side effects of mirtazapine include dizziness, drowsiness, lightheadedness, increased appetite, weight gain, dry mouth, or constipation. Notify your doctor or pharmacist if these effects persist or worsen.
• To alleviate dry mouth, consider using sugarless hard candy or ice chips, chewing sugarless gum, drinking water, or using a saliva substitute.
• This medication is prescribed because its benefits outweigh the potential risks for most individuals. Serious side effects are uncommon but inform your doctor promptly if you experience swelling of the hands/feet, shaking (tremor), or confusion.
• Seek immediate medical attention for very serious side effects, including fast/irregular heartbeat, severe dizziness, fainting, eye pain/swelling/redness, widened pupils, vision changes, or symptoms of serotonin syndrome/toxicity (e.g., fast heartbeat, hallucinations, loss of coordination, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness).
• While a severe allergic reaction is rare, seek immediate medical help if you observe symptoms such as fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing.
• This list does not encompass all possible side effects. Contact your doctor or pharmacist if you notice any unlisted effects.

• Prior to taking mirtazapine, inform your doctor or pharmacist about any allergies you may have, as this medication could contain inactive ingredients that may cause allergic reactions.
• Disclose your medical history, particularly if you have a history or family history of psychiatric disorders, suicide attempts, liver or kidney disease, seizures, high cholesterol or triglyceride levels, heart disease, stroke, severe dehydration, low blood pressure, or glaucoma (angle-closure type).
• Mirtazapine may lead to a heart rhythm condition called QT prolongation, which can be serious or fatal. Notify your doctor if you have certain heart problems, a family history of such problems, or conditions like low potassium or magnesium levels. Discuss the safe use of mirtazapine with your doctor.
• This medication may cause dizziness or drowsiness. Avoid activities requiring alertness, such as driving or using machinery. Limit alcohol consumption and discuss marijuana use with your doctor.
• Older adults may be more susceptible to the side effects of mirtazapine, especially drowsiness and QT prolongation.
• During pregnancy, use mirtazapine only when necessary. If used in the last 3 months of pregnancy, your newborn may rarely develop symptoms such as feeding or breathing difficulties, seizures, muscle stiffness, jitteriness, or constant crying. Report any such symptoms promptly. Do not discontinue the medication without your doctor’s guidance. If planning pregnancy, consult your doctor about the risks and benefits.
• Mirtazapine passes into breast milk. Consult your doctor before breastfeeding.
• This information is not exhaustive; for additional details, consult your doctor or pharmacist.

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