Drug name: Esbriet
Generic name: Pirfenidone
This medication is used to treat idiopathic pulmonary fibrosis (IPF), a kind of lung illness. This illness causes scarring and stiffening of the lungs, making it difficult to breathe. This medication may also be able to help reduce the progression of your IPF.
Esbriet mechanism of action
The exact mechanism of action of Esbriet is unknown, although it is thought to interfere with the synthesis of tiny proteins in the body that are involved in inflammation and cell growth. This medication works on a number of pathways that may be implicated in lung scarring.
Before you start taking pirfenidone, and each time you obtain a refill, read the Patient Information Leaflet if one is available from your pharmacist. If you have any concerns, make sure to contact your doctor or pharmacist.
OnlineCanadianPharmacy has this available in 200mg strength so if you receive a prescription from your doctor for the Esbriet 267 mg, we will need approval from your physician before we can dispense the 200mg. Enoxacin, ciprofloxacin, and fluvoxamine may interact with Esbriet. Inform your doctor about all of your medicines and supplements. If you’re pregnant, planning to become pregnant, or nursing, tell your doctor.
Take this medicine by mouth with meals three times a day or as prescribed by your doctor. Taking pirfenidone with meals might assist with nausea and dizziness. Your doctor may advise you to begin taking this medicine at a low dose and gradually raise it to decrease the chance of adverse effects. Carefully follow your doctor’s recommendations.
Esbriet side effects
- Loss of appetite
- Stomach pain
- Upset stomach
- Feeling tired
- Weight loss
- Cold symptoms
- Joint pain
- Sleep problems
- Severe allergic reaction
- Severe persistent stomach pain, vomiting, or diarrhea
- Burning sensation in your throat
- Liver problems:
- Upper right stomach pain
- Easy bruising / bleeding o Feeling tired
- Dark urine
- Clay colored stools
This drug might cause serious adverse effects. If you have any significant side effects, contact your doctor immediately, or dial 911 or your local emergency number.
These aren’t the only adverse effects that come with it. Other, perhaps more rare side effects should be discussed with your doctor and pharmacist. Before taking this medicine, tell your doctor about any allergies you have, medications you are taking, and any previous medical history you have.
Ofev vs Esbriet
According to a research based on real-world data, two authorized anti-fibrotic medications are proven to be safe and efficient in the treatment of idiopathic pulmonary fibrosis (IPF). Esbriet (pirfenidone) and Ofev (nintedanib) improved progression-free survival, delayed lung function loss, and lowered death in IPF patients, according to the recent clinical findings. In the early phases of therapy, Ofev looks to be more tolerated than Esbriet, suggesting it may be the preferred first-line drug.
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