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Indications

• Canagliflozin is used with diet and exercise to control high blood sugar in type 2 diabetes.
• Helps prevent kidney damage, blindness, nerve problems, limb loss, and sexual function issues.
• Used by those with type 2 diabetes and heart disease to lower the risk of heart attack or stroke.
• Used by those with type 2 diabetes and kidney disease to reduce the risk of dialysis, death from heart disease, and hospitalization for heart failure.
• Mechanism: Increases sugar removal by the kidneys.

Dosage and administration

• Read the Medication Guide provided by the pharmacist before starting canagliflozin and with each refill.
• Take canagliflozin orally as directed by the doctor, usually once daily before the first meal.
• Dosage depends on medical condition, response to treatment, and other medications.
• Inform doctor and pharmacist about all products used, including prescription, nonprescription, and herbal products.
• Take the medication regularly at the same time each day for maximum benefit.
• Inform the doctor if the condition does not improve or worsens, such as persistent or increasing high blood sugar.

Side effects

• Possible side effects of canagliflozin: frequent urination, dry mouth, dizziness, lightheadedness.
• If these effects persist or worsen, inform your doctor or pharmacist.
• To reduce dizziness, rise slowly from a sitting or lying position.
• Medication is prescribed based on benefits outweighing risks; many users experience no serious side effects.
• Immediately report serious side effects: signs of bladder infection, kidney problems, high potassium levels.
• Seek medical help for serious symptoms: unusual tiredness, nausea/vomiting, abdominal pain, trouble breathing.
• Risk of yeast infection in genitals; report signs promptly; rare risk of Fournier’s gangrene, seek immediate help for pain/redness/swelling with fever.
• Canagliflozin usually does not cause low blood sugar; follow prescribed schedule, carry glucose for emergencies.
• High blood sugar symptoms: increased thirst/urination; notify doctor for adjustments.
• Rare risk of lower limb loss; inform the doctor of any leg/foot pain, tenderness, redness, swelling, or sores.
• Potential dehydration risk; drink fluids; report changes in fluid intake or signs of dehydration.
• May cause bone loss or fractures; adopt a healthy lifestyle, consider supplements; consult a doctor.
• Rare but serious allergic reactions may occur; seek immediate medical help for symptoms like rash, swelling, severe dizziness, trouble breathing.
• Not an exhaustive list; contact a doctor or pharmacist for other potential side effects.

Precautions

• Inform your doctor or pharmacist of any allergies to canagliflozin or other substances; inactive ingredients may cause reactions.
• Disclose medical history, especially kidney disease, pancreatitis, dehydration, alcohol use, low blood pressure, heart failure, mineral imbalances, and history of yeast infections.
• Blurred vision, dizziness, or drowsiness may occur due to low or high blood sugar; avoid activities requiring alertness until sure it’s safe.
• Limit alcohol intake to reduce the risk of low blood sugar and high ketone levels.
• Stress, fever, infection, injury, or surgery may affect blood sugar control; consult your doctor for potential treatment plan adjustments.
• Inform healthcare providers about all products used before surgery (prescription, non-prescription, and herbal).
• Older adults may be more sensitive to side effects, including dizziness, dehydration, and bone loss.
• During pregnancy, use canagliflozin only if necessary; discuss risks and benefits with your doctor.
• Pregnancy may affect diabetes, plan blood sugar management with your doctor.
• Unknown if the drug passes into breast milk; consult your doctor before breastfeeding.