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Indications

• Pioglitazone is a diabetes medication, belonging to the thiazolidinedione class, used to control high blood sugar in individuals with type 2 diabetes.
• It is administered in conjunction with a proper diet and exercise regimen to prevent complications associated with diabetes, including kidney damage, blindness, nerve problems, limb loss, and sexual function issues.
• The drug works by restoring the body’s proper response to insulin, thereby lowering blood sugar levels.
• Pioglitazone can be used alone or in combination with other diabetes medications, such as metformin or glyburide.
• Patients are advised to consult with their doctor regarding the risks and benefits of pioglitazone.

Dosage and administration

• Before using pioglitazone, read the Medication Guide provided by your pharmacist.
• Take this medication by mouth with or without food as directed by your doctor, usually once daily.
• The dosage is determined based on your medical condition, response to treatment, and other medications you may be taking.
• Inform your doctor and pharmacist about all the products you use, including prescription drugs, nonprescription drugs, and herbal products.
• Take this medication regularly to maximize its benefits and try to take it at the same time each day.
• It may take 2 to 3 months before the full benefits of the drug take effect.
• Report to your doctor if your condition does not improve or worsens, such as if your blood sugar remains too high or too low.

Side effects

• Possible common side effects of pioglitazone include sore throat, muscle pain, weight gain, or tooth problems.
• If these effects persist or worsen, notify your doctor or pharmacist promptly.
• Remember that the benefits of this medication, prescribed by your doctor, outweigh the potential risks for most people.
• Report to your doctor immediately if you experience serious side effects, including new or worsening vision problems, bone fracture, reddish-colored urine, urgent or painful urination, or signs of liver disease.
• Pioglitazone generally does not cause low blood sugar but may do so when combined with other diabetes medications. Symptoms include sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in hands/feet.
• Carry glucose tablets or gel to treat low blood sugar and consult with your doctor or pharmacist about what to do if you miss a meal.
• Symptoms of high blood sugar include increased thirst/urination. Notify your doctor if these symptoms occur.
• Seek immediate medical attention if you experience a rare but serious allergic reaction, characterized by rash, itching/swelling (especially of the face/tongue/throat), dizziness, or trouble breathing.
• This list does not cover all possible side effects, so contact your doctor or pharmacist for any concerns or effects not mentioned here.

Precautions

• Inform your doctor or pharmacist about any allergies you have before taking pioglitazone, as it may contain inactive ingredients that could cause allergic reactions.
• Share your medical history, particularly heart disease, liver disease, fluid in the lungs, swelling (edema), anemia, macular edema (a specific eye problem), or bladder cancer.
• Be cautious about activities requiring alertness or clear vision, as pioglitazone may cause blurred vision, dizziness, or drowsiness due to low or high blood sugar.
• Limit alcohol intake, as it can increase the risk of low blood sugar.
• In stressful situations like fever, infection, injury, or surgery, consult your doctor, as stress may require adjustments to your treatment plan, medications, or blood sugar testing.
• Before undergoing surgery, inform your doctor or dentist about all the products you use, including prescription drugs, nonprescription drugs, and herbal products.
• Pioglitazone may increase the risk of bone fracture in women, typically in the upper arm, hand, or foot.
• The medication can affect the menstrual cycle, promote ovulation, and increase the risk of pregnancy. Discuss reliable birth control methods with your doctor or pharmacist.
• During pregnancy, use pioglitazone only when necessary, and discuss potential risks and benefits with your doctor. Insulin may be substituted for this drug during pregnancy.
• It is unknown if the drug passes into breast milk, so consult your doctor before breastfeeding.