Rexulti is indicated for the treatment of schizophrenia in adults.
It is prescribed to help manage symptoms such as hallucinations, delusions, disorganized thinking, and emotional withdrawal associated with schizophrenia.
Rexulti may also be used as an adjunctive therapy for the treatment of major depressive disorder (MDD) in adults, when used alongside an antidepressant medication.
Dosage and administration
The recommended starting dosage of Rexulti for schizophrenia in adults is 1 mg orally once daily.
The dosage may be increased to a target dosage range of 2 to 4 mg orally once daily, based on individual response and tolerability.
For the adjunctive treatment of major depressive disorder (MDD) in adults, the recommended starting dosage of Rexulti is 0.5 mg orally once daily.
The dosage may be increased to a target dosage range of 1 to 3 mg orally once daily, based on individual response and tolerability.
Rexulti can be taken with or without food.
It is important to take Rexulti at the same time each day as directed by your healthcare provider.
Do not stop taking Rexulti suddenly without consulting your healthcare provider, as abrupt discontinuation may lead to withdrawal symptoms.
If a dose of Rexulti is missed, take it as soon as remembered, unless it is close to the time of the next scheduled dose. Do not double the dose to catch up.
Store Rexulti at room temperature away from moisture and heat.
Side effects
Common side effects of Rexulti may include weight gain, akathisia (restlessness or inner agitation), and sedation.
Some individuals may experience gastrointestinal symptoms such as nausea, constipation, or vomiting while taking Rexulti.
Rexulti may increase the risk of metabolic changes, including elevated blood sugar levels or lipid abnormalities.
Other potential side effects include headache, insomnia, or tremor.
Rexulti may cause orthostatic hypotension, leading to symptoms such as dizziness or fainting upon standing.
In some cases, Rexulti may increase the risk of suicidal thoughts or behaviors, particularly in young adults.
Report any new or worsening symptoms to your healthcare provider, especially if they are severe or persistent.
Seek medical attention if you experience symptoms of a serious allergic reaction to Rexulti, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
Precautions
Inform your healthcare provider about any history of mood disorders, suicidal thoughts, or substance abuse before starting Rexulti.
Discuss with your healthcare provider if you have any medical conditions such as diabetes, cardiovascular disease, or seizures, as Rexulti may exacerbate these conditions.
Use caution when driving or operating machinery, as Rexulti may cause drowsiness or dizziness.
Avoid sudden discontinuation of Rexulti without consulting your healthcare provider, as it may lead to withdrawal symptoms.
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Rexulti with your healthcare provider.
Be vigilant for signs of serotonin syndrome, especially when taking Rexulti in combination with other serotonergic medications.
Monitor for changes in mood or behavior, especially in young adults and adolescents, as Rexulti may increase the risk of suicidal thoughts or behaviors.
Keep Rexulti out of reach of children and pets and store it at room temperature away from moisture and heat.
Additional information
Brand Name:
Rexulti
Scientific Name:
Brexpiprazole
Other Names:
Rexulti
Strength(s):
0.5mg, 0.25mg, 1mg, 2mg, 3mg, 4mg
Quantities Available:
30, 90
Formulation:
Tablet
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Rexulti
