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Indications

• Medication used alone or with other drugs to prevent nausea and vomiting from chemotherapy and radiation therapy for cancer.
• Also used to prevent and treat nausea and vomiting after surgery.
• Blocks serotonin, a natural substance in the body that triggers vomiting.

Dosage and administration

• Take medication for chemotherapy-related nausea 30 minutes before treatment, for radiation treatment 1-2 hours before, and for surgery 1 hour before.
• May be taken with or without food but follow doctor’s advice on eating before treatment.
• Use a special measuring device for the liquid form, not a household spoon.
• Follow doctor’s directions for additional doses, up to 3 times a day for 1-2 days post-treatment.
• Take regularly on a prescribed schedule for maximum benefit.
• Dosage depends on medical condition, response to therapy, and for children, may be based on age and weight.
• Maximum dose for severe liver problems is 8 milligrams in 24 hours.
• Take exactly as directed; do not exceed prescribed dosage or frequency.
• Inform the doctor if the condition does not improve or worsens.

Side effects

• Possible side effects: headache, lightheadedness, dizziness, drowsiness, tiredness, constipation.
• If effects persist or worsen, inform the doctor..
• To reduce dizziness and lightheadedness, rise slowly from sitting or lying position.
• Medication prescribed considering benefits outweigh risks.
• Serious side effects: stomach pain, muscle spasm/stiffness, vision changes.
• Very serious side effects: chest pain, irregular heartbeat, severe dizziness, fainting.
• Risk of serotonin syndrome; inform doctor of all medications.
• Symptoms of serotonin syndrome: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
• Rare but serious allergic reaction; seek medical help for symptoms like rash, itching/swelling, severe dizziness, trouble breathing.
• Not a complete list of side effects; contact doctor/pharmacist for other effects.

Precautions

• Inform doctor/pharmacist of allergies to ondansetron or serotonin blockers.
• Check for inactive ingredients that may cause allergic reactions.
• Share medical history, especially irregular heartbeat, liver disease, stomach/intestinal issues.
• Ondansetron may cause QT prolongation, leading to serious/fast/irregular heartbeat.
• Risk may increase with certain medical conditions or drugs; disclose all medications and relevant conditions.
• Low potassium/magnesium levels may elevate QT prolongation risk; discuss use of ondansetron with the doctor.
• Medication can cause dizziness or drowsiness; avoid alcohol/marijuana, be cautious with activities requiring alertness.
• Older adults may be more sensitive to side effects, particularly QT prolongation.
• Use during pregnancy only if necessary; discuss risks and benefits with the doctor.
• Unknown if the drug passes into breast milk; consult doctor before breastfeeding.