Savella is indicated for the management of fibromyalgia, a chronic condition characterized by widespread musculoskeletal pain and tenderness.
It is prescribed to help reduce pain and improve physical function in adults with fibromyalgia.
Savella may also be used to alleviate other symptoms associated with fibromyalgia, such as fatigue and sleep disturbances.
Dosage and administration
The recommended starting dosage of Savella for adults with fibromyalgia is 12.5 mg orally once daily for the first week.
After the first week, the dosage is usually increased to 50 mg orally twice daily.
Savella can be taken with or without food.
Dosage adjustments may be made based on individual response and tolerability, with increments of 25 mg per day every 2 to 7 days, up to a maximum dosage of 100 mg orally twice daily.
If discontinuation of Savella is necessary, gradual dose reduction is recommended to minimize the risk of withdrawal symptoms.
Always follow the dosage instructions provided by your healthcare provider.
Side effects
Common side effects of Savella may include nausea, headache, dizziness, and insomnia.
Some individuals may experience dry mouth, constipation, or sweating as side effects of Savella.
Savella may cause changes in blood pressure, leading to symptoms such as orthostatic hypotension (dizziness upon standing).
Other potential side effects include palpitations, hot flushes, or urinary hesitation.
In some cases, Savella may increase the risk of suicidal thoughts or behaviors, particularly in young adults.
Report any new or worsening symptoms to your healthcare provider, especially if they are severe or persistent.
Seek medical attention if you experience signs of serotonin syndrome, such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Precautions
Inform your healthcare provider about any history of seizures, bipolar disorder, or other psychiatric conditions before starting Savella.
Use caution when driving or operating machinery, as Savella may cause dizziness or drowsiness.
Avoid abrupt discontinuation of Savella, as it may lead to withdrawal symptoms such as headache, nausea, and irritability.
Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Savella during pregnancy and lactation is not well-established.
Be vigilant for signs of serotonin syndrome, especially when taking Savella in combination with other serotonergic medications.
If you have a history of glaucoma or urinary retention, discuss the risks and benefits of Savella with your healthcare provider before starting treatment.
Monitor for changes in mood or behavior, especially in young adults and adolescents, as Savella may increase the risk of suicidal thoughts or behaviors.
Additional information
Brand Name:
Savella
Scientific Name:
Milnacipran
Other Names:
Milnace, Milza
Strength(s):
25mg, 50mg
Quantities Available:
100
Formulation:
Capsule, Tablet
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Milnacipran
