DILANTIN treats tonic-clonic and psychomotor seizures.
It also prevents and treats seizures during or after neurosurgery.
Dosage and administration
Adult starting dose: 100 mg DILANTIN extended capsule three times daily, with adjustments as needed.
Satisfactory maintenance dose for most adults: One capsule three to four times daily, possibly increasing to two capsules three times daily if necessary.
Once-a-day dosage for adults: Consider 300 mg DILANTIN extended capsule if seizure control is established with three daily doses.
Adult loading dose: For rapid steady-state serum levels in clinic or hospital settings, refer to full prescribing information.
Pediatric starting dose: 5 mg/kg/day in two to three equally divided doses, up to a maximum of 300 mg daily. Maintenance dosage: 4 to 8 mg/kg/day.
Serum blood level determinations may be necessary for optimal dosage adjustments, with clinically effective serum total concentration of 10 to 20 mcg/mL (unbound phenytoin concentration: 1 to 2 mcg/mL).
Side effects
Nystagmus
Ataxia
Slurred speech
Decreased coordination
Somnolence
Mental confusion.
Precautions
Withdrawal Precipitated Seizure: May cause status epilepticus; dose reductions or discontinuation should be gradual.
Suicidal Behavior and Ideation: Monitor for depression, suicidal thoughts, or unusual mood or behavior changes.
Serious Dermatologic Reactions: Discontinue at first sign of rash; if suggestive of SJS/TEN, discontinue permanently and consider alternative therapy.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan Hypersensitivity: Evaluate immediately for signs of hypersensitivity; discontinue if alternative cause cannot be established.
Cardiac Effects: Reports of bradycardia and cardiac arrest.
Angioedema: Discontinue if symptoms like facial swelling occur.
Hepatic Injury: Cases of acute hepatotoxicity reported; discontinue immediately.
Hematopoietic Complications: If occurs, follow-up observation needed; consider alternative treatment.
Additional information
Brand Name:
Dilantin
Scientific Name:
Phenytoin Sodium
Other Names:
Dilantin, Epanutin Sodium, Epsolin
Strength(s):
30mg, 100mg
Quantities Available:
100, 200, 300
Formulation:
Capsule, ER Capsule, Tablet
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Dilantin
Phenytoin Sodium
